Chunlei Zheng

2026

Sodium-Glucose Cotransporter 2 Inhibitors and Dementia Risk in Patients With Psychiatric Disorders.

David T. Liebers^†, Tianshe He^†, Rebecca A. Betensky, Chunlei Zheng, Kaitlin N. Swinnerton, Sean Jacobson, Linden Huhmann, Mary T. Brophy, Nhan V. Do, Paola Gilsanz, Ricardo S. Osorio, Nunzio Pomara, Antonio Convit, Donald C. Goff, Dan V. Iosifescu, Nathanael R. Fillmore, Jaime Ramos-Cejudo^† Equal first authorship

JAMA Network Open9(6), e2619985

U.S. Veterans and VA Data Retrospective Cohort Study Electronic Health Records Alzheimer Disease and Dementia SGLT2 Inhibitors

2026

A deep learning model to dynamically predict cancer-associated thromboembolism in large-scale healthcare systems.

Tianshe He^†, Chunlei Zheng^†, Jennifer La, Dang Pham, Omid Jafari, Jamie Strampe, Karlynn Dulberger, Jaime Ramos-Cejudo, J. Michael Gaziano, Nhan V. Do, Vipul Chitalia, Katya Ravid, Ang Li^‡, Nathanael R. Fillmore^‡† Equal first authorship · ^‡ Equal senior authorship

npj Digital Medicine

U.S. Veterans and VA Data Electronic Health Records Cancer-Associated Thrombosis Predictive Modeling External Validation

2026

Neutrophil inflammation metrics are associated with the risk of future dementia in large data from NYU Langone Hospitals and the Veterans Health Administration.

Tianshe He, Rebecca A. Betensky, Ricardo S. Osorio, Kaitlin Swinnerton, Chunlei Zheng, Tovia Jacobs, Alok Vedvyas, Karyn Marsh, Joshua Chodosh, Ula Y. Hwang, Natalia Sifnugel, Omonigho M. Bubu, Thomas Wisniewski, Mary Brophy, Nhan V. Do, Nathanael R. Fillmore^‡, Jaime Ramos-Cejudo^‡‡ Equal senior authorship

Alzheimer's & Dementia22(4), e71335

U.S. Veterans and VA Data Retrospective Cohort Study Electronic Health Records Alzheimer Disease and Dementia Risk Factors

2026

Identification of Risk Factors for Acral Melanoma in US Veterans.

Jonathan C. Hwang^†, Linden B. Huhmann^†, Kelly Cho, Sergey D. Goryachev, Nicholas Starink, Martin A. Weinstock, Maryam M. Asgari, Christy Zheng, Charles Lu, Theodore C. Feldman, Nhan V. Do, John M. Gaziano, Yevgeniy R. Semenov, Marc S. Hurlbert, Nathanael R. Fillmore^‡, Rebecca I. Hartman^‡† Equal first authorship · ^‡ Equal senior authorship

JAMA Dermatology162(3), 279-291

Acral Melanoma Agent Orange Exposure U.S. Veterans and VA Data VA Cancer Registry Nested Case-Control Study

2025

Rapid Support and Implementation of an Application for the Prediction Augmented Screening Initiative (PASI) Planning Phase Through the Enabling Technologies for Rapid Learning Health Systems Platform (ENTHRALL) at the Department of Veterans Affairs (VA).

Hannah M. Tosi, Chunlei Zheng, Amelia H. Tarren, Meghana Yellanki, Stephen J. Miller, Oleg V. Soloviev, June K. Corrigan, George R. Schneeloch, Hormuzd A. Katki, Lauren E. Kearney, Tanner J. Caverly, Nichole T. Tanner, Renda Soylemez Wiener, Mary Brophy, Nathanael R. Fillmore, Nhan V. Do, Danne C. Elbers

Cancer Informatics24, 11769351251389781

U.S. Veterans and VA Data Electronic Health Records Lung Cancer Natural Language Processing Learning Health Systems

2025

Pancreatic cancer risk prediction using deep sequential modeling of longitudinal diagnostic and medication records.

Chunlei Zheng^†, Asif Khan^†, Daniel Ritter^†, Debora S. Marks, Nhan V. Do, Nathanael R. Fillmore^‡, Chris Sander^‡† Equal first authorship · ^‡ Equal senior authorship

Cell Reports Medicine6(9), 102359

U.S. Veterans and VA Data Electronic Health Records Pancreatic Cancer Predictive Modeling Deep Learning

2025

Multimorbidity and Its Impact in Older U.S. Veterans Newly Treated for Advanced Non-Small Cell Lung Cancer.

Joseph R. Larsen^†, Chunlei Zheng^†, Jennifer La, Julie Tsu-Yu Wu, Michael Kelley, J. Michael Gaziano, Mary Brophy, Nhan V. Do, Dae H. Kim, Jane A. Driver, Clark DuMontier^‡, Nathanael R. Fillmore^‡† Equal first authorship · ^‡ Equal senior authorship

Annals of the American Thoracic Society22(4), 598-608

U.S. Veterans and VA Data Retrospective Cohort Study Lung Cancer Overall Survival Geriatric Oncology

2024

Antidepressant exposure and long-term dementia risk in a nationwide retrospective study on US veterans with midlife major depressive disorder.

Jaime Ramos-Cejudo^†, June K. Corrigan^†, Chunlei Zheng, Kaitlin N. Swinnerton, Sean R. Jacobson, Jennifer La, Rebecca A. Betensky, Ricardo S. Osorio, Sharon Madanes, Nunzio Pomara, Dan Iosifescu, Mary Brophy, Nhan V. Do^‡, Nathanael R. Fillmore^‡† Equal first authorship · ^‡ Equal senior authorship

Alzheimer's & Dementia20(6), 4106-4114

U.S. Veterans and VA Data Retrospective Cohort Study Alzheimer Disease and Dementia Major Depressive Disorder Antidepressant Therapy

2024

Matching Patients to Accelerate Clinical Trials (MPACT): Enabling Technology for Oncology Clinical Trial Workflow.

Nhan V. Do, Danne C. Elbers, Nathanael R. Fillmore, Samuel Ajjarapu, Steven J. Bergstrom, John Bihn, June K. Corrigan, Rupali Dhond, Svitlana Dipietro, Arkadiy Dolgin, Theodore C. Feldman, Sergey D. Goryachev, Linden B. Huhmann, Jennifer La, Paul A. Marcantonio, Kyle M. McGrath, Stephen J. Miller, Vinh Q. Nguyen, George R. Schneeloch, Feng-Chi Sung, Kaitlin N. Swinnerton, Amelia H. Tarren, Hannah M. Tosi, Danielle Valley, Austin D. Vo, Cenk Yildirim, Chunlei Zheng, Robert Zwolinski, Gisele A. Sarosy, David Loose, Colleen Shannon, Mary T. Brophy

Studies in Health Technology and Informatics310, 1086-1090

U.S. Veterans and VA Data Electronic Health Records Natural Language Processing Clinical Trial Enrollment Patient Screening Workflow

2023

A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories.

Davide Placido^†, Bo Yuan^†, Jessica X. Hjaltelin^†, Chunlei Zheng^†, Amalie D. Haue, Piotr J. Chmura, Chen Yuan, Jihye Kim, Renato Umeton, Gregory Antell, Alexander Chowdhury, Alexandra Franz, Lauren Brais, Elizabeth Andrews, Debora S. Marks, Aviv Regev, Siamack Ayandeh, Mary T. Brophy, Nhan V. Do, Peter Kraft, Brian M. Wolpin, Michael H. Rosenthal, Nathanael R. Fillmore, Søren Brunak^‡, Chris Sander^‡† Equal first authorship · ^‡ Equal senior authorship

Nature Medicine29(5), 1113-1122

U.S. Veterans and VA Data Electronic Health Records Pancreatic Cancer Predictive Modeling Deep Learning

2022

The COVID-19 hospitalization metric in the pre- and postvaccination eras as a measure of pandemic severity: A retrospective, nationwide cohort study.

Nathanael R. Fillmore^†, Jennifer La^†, Chunlei Zheng, Shira Doron, Nhan V. Do, Paul A. Monach^‡, Westyn Branch-Elliman^‡† Equal first authorship · ^‡ Equal senior authorship

Infection Control and Hospital Epidemiology43(12), 1767-1772

U.S. Veterans and VA Data Retrospective Cohort Study COVID-19 Vaccine Effectiveness Hospitalization Metrics

2022

Potential long-term effect of tumor necrosis factor inhibitors on dementia risk: A propensity score matched retrospective cohort study in US veterans.

Chunlei Zheng^†, Nathanael R. Fillmore^†, Jaime Ramos-Cejudo, Mary Brophy, Ricardo Osorio, Mark E. Gurney, Wei Qiao Qiu, Rhoda Au, George Perry, Maureen Dubreuil, Shu G. Chen, Xin Qi, Pamela B. Davis, Nhan Do, Rong Xu^† Equal first authorship

Alzheimer's & Dementia18(6), 1248-1259

U.S. Veterans and VA Data Retrospective Cohort Study TNF Inhibitors Alzheimer Disease and Dementia Propensity Score Matching

2022

Platelet Function Is Associated With Dementia Risk in the Framingham Heart Study.

Jaime Ramos-Cejudo, Andrew D. Johnson, Alexa Beiser, Sudha Seshadri, Joel Salinas, Jeffrey S. Berger, Nathanael R. Fillmore, Nhan Do, Chunlei Zheng, Zanetta Kovbasyuk, Babak A. Ardekani, Nunzio Pomara, Omonigho M. Bubu, Ankit Parekh, Antonio Convit, Rebecca A. Betensky, Thomas M. Wisniewski, Ricardo S. Osorio

Journal of the American Heart Association11(9), e023918

Alzheimer Disease and Dementia Framingham Heart Study Light Transmission Aggregometry Platelet Function Inverse Probability Weighting

2022

Impact of prior SARS-CoV-2 infection on incidence of hospitalization and adverse events following mRNA SARS-CoV-2 vaccination: A nationwide, retrospective cohort study.

Lucy L. Li^†, Chunlei Zheng^†, Jennifer La, Nhan V. Do, Paul A. Monach, Judith M. Strymish, Nathanael R. Fillmore^‡, Westyn Branch-Elliman^‡† Equal first authorship · ^‡ Equal senior authorship

Vaccine40(8), 1082-1089

U.S. Veterans and VA Data Retrospective Cohort Study COVID-19 Vaccine Effectiveness mRNA Vaccines

2021

The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study.

Jaime Ramos-Cejudo, Andrew D. Johnson, Alexa Beiser, Sudha Seshadri, Joel Salinas, Jeffrey S. Berger, Nathanael R. Fillmore, Nhan Do, Chunlei Zheng, Zanetta Kovbasyuk, Babak A. Ardekani, Omonigho M. Bubu, Ankit Parekh, Antonio Convit, Rebecca A. Betensky, Thomas M. Wisniewski, Ricardo S. Osorio

Frontiers in Aging Neuroscience13, 773984

Alzheimer Disease and Dementia Framingham Heart Study Neutrophil-to-Lymphocyte Ratio Cox Proportional Hazards Model Inverse Probability Weighting