Nathanael R. Fillmore
Themes / Risk Stratification and Epidemiology of Cancer-Associated Thrombosis
Line of work

Risk Stratification and Epidemiology of Cancer-Associated Thrombosis

This research develops and validates predictive models for venous thromboembolism (VTE) in oncology patients. It integrates electronic health record data, plasma proteomics, and circulating tumor DNA to improve upon traditional risk scores like the Khorana score.

Cancer-Associated Thrombosis Predictive Modeling External Validation Risk Stratification

Anchor result

The EHR-CAT score demonstrated superior discrimination over the Khorana score, reclassifying 20% of patients and significantly improving VTE capture.

Related publications

2026

Development and validation of venous thromboembolism-bidirectional encoder representations from transformers (VTE-BERT) natural language processing model.

Omid Jafari, Shengling Ma, Barbara D. Lam, Jun Y. Jiang, Emily Zhou, Mrinal Ranjan, Justine Ryu, Raka Bandyo, Arash Maghsoudi, Bo Peng, Christopher I. Amos, Abiodun Oluyomi, Nathanael R. Fillmore, Jennifer La‡, Ang Li‡‡ Equal senior authorship

Journal of Thrombosis and Haemostasis24(7), 2522-2531
Natural Language Processing External Validation Clinical Notes Radiology and Pathology Reports Cancer Patients
2026

A deep learning model to dynamically predict cancer-associated thromboembolism in large-scale healthcare systems.

Tianshe He†, Chunlei Zheng†, Jennifer La, Dang Pham, Omid Jafari, Jamie Strampe, Karlynn Dulberger, Jaime Ramos-Cejudo, J. Michael Gaziano, Nhan V. Do, Vipul Chitalia, Katya Ravid, Ang Li‡, Nathanael R. Fillmore‡† Equal first authorship · ‡ Equal senior authorship

npj Digital Medicine
U.S. Veterans and VA Data Electronic Health Records Cancer-Associated Thrombosis Predictive Modeling External Validation
2025

Dietary tryptophan augments cancer-associated venous thrombogenicity mitigated by indoleamine 2,3-dioxygenase 1 inhibition.

Saran Lotfollahzadeh†, Asha Jose†, Xiaosheng Yang, Tanvi Bathla, Adam Lazowski, Isaac Hoekstra, Kashvi Sethuraman, Sowmya Potluri, Karlynn N. Dulberger, Jennifer La, Nathanael R. Fillmore, Maria Del Carmen Piqueras, Norman Lee, Howard Cabral, Katya Ravid, Vipul C. Chitalia† Equal first authorship

Blood Advances9(19), 4910-4923
Cancer-Associated Thrombosis Colon Cancer Cardio-Oncology Dietary Tryptophan Indoleamine 2,3-Dioxygenase 1 Inhibition
2025

External validation of a novel cancer-associated venous thromboembolism risk assessment score in a safety-net hospital.

Karlynn N. Dulberger†, Jennifer La†, Ang Li†, Saran Lotfollahzadeh, Asha Jose, Nhan V. Do, Mary T. Brophy, J. Michael Gaziano, Katya Ravid, Vipul C. Chitalia, Nathanael R. Fillmore† Equal first authorship

Research and Practice in Thrombosis and Haemostasis9(1), 102650
Cancer-Associated Thrombosis External Validation Electronic Health Records Retrospective Cohort Study Cancer Patients
2024

Thrombosis risk prediction in lymphoma patients: A multi-institutional, retrospective model development and validation study.

Shengling Ma†, Jennifer La†, Kaitlin N. Swinnerton, Danielle Guffey, Raka Bandyo, Las Pozas Giordana De, Katy Hanzelka, Xiangjun Xiao, Cristhiam M. Rojas-Hernandez, Christopher I. Amos, Vipul Chitalia, Katya Ravid, Kelly W. Merriman, Christopher R. Flowers, Nathanael Fillmore‡, Ang Li‡† Equal first authorship · ‡ Equal senior authorship

American Journal of Hematology99(7), 1230-1239
U.S. Veterans and VA Data Retrospective Cohort Study Cancer-Associated Thrombosis Lymphoma Predictive Modeling
2023

External validation of a novel electronic risk score for cancer-associated thrombosis in a comprehensive cancer center.

Ang Li, Las Pozas Giordana De, Clark R. Andersen, Chijioke C. Nze, Katy M. Toale, Emily M. Milner, Nathanael R. Fillmore, Elizabeth Yu Chiao, Hernandez Cristhiam Rojas, Michael H. Kroll, Kelly W. Merriman‡, Christopher R. Flowers‡‡ Equal senior authorship

American Journal of Hematology98(7), 1052-1057
Cancer-Associated Thrombosis Electronic Health Records External Validation Model Validation Natural Language Processing
2023

Derivation and Validation of a Clinical Risk Assessment Model for Cancer-Associated Thrombosis in Two Unique US Health Care Systems.

Ang Li†, Jennifer La†, Sarah B. May, Danielle Guffey, Costa Wilson L. da, Christopher I. Amos, Raka Bandyo, Emily M. Milner, Karen M. Kurian, Daniel C. R. Chen, Nhan V. Do, Carolina Granada, Nimrah Riaz, Mary T. Brophy, Vipul Chitalia, J. Michael Gaziano, David A. Garcia, Marc Carrier, Christopher R. Flowers, Neil A. Zakai‡, Nathanael R. Fillmore‡† Equal first authorship · ‡ Equal senior authorship

Journal of Clinical Oncology41(16), 2926-2938
Cancer-Associated Thrombosis Predictive Modeling Retrospective Cohort Study External Validation U.S. Veterans and VA Data
2023

Epidemiology of Cancer-Associated Venous Thromboembolism in Patients With Solid and Hematologic Neoplasms in the Veterans Affairs Health Care System.

Kylee L. Martens†, Ang Li†, Jennifer La, Sarah B. May, Kaitlin N. Swinnerton, Hannah Tosi, Danne C. Elbers, Nhan V. Do, Mary T. Brophy, J. Michael Gaziano, Saran Lotfollahzadeh, Vipul Chitalia, Katya Ravid, Nathanael R. Fillmore† Equal first authorship

JAMA Network Open6(6), e2317945
U.S. Veterans and VA Data Retrospective Cohort Study Electronic Health Records Cancer-Associated Thrombosis Health Disparities