Nathanael R. Fillmore
Themes / SARS-CoV-2 Outcomes in Immunocompromised and Cancer Populations
Line of work

SARS-CoV-2 Outcomes in Immunocompromised and Cancer Populations

This research analyzes the susceptibility, severity, and vaccination response of patients with cancer and other immune-mediated conditions during the COVID-19 pandemic. It utilizes large-scale cohort data to refine severity metrics and identify high-risk subgroups.

COVID-19 Severe COVID-19 Vaccination Vaccine Effectiveness

Anchor result

COVID-19 vaccination showed a 58% overall effectiveness in cancer patients, though effectiveness was notably lower in those receiving chemotherapy.

Related publications

2025

Leveraging near-real-time patient and population data to incorporate fluctuating risk of severe COVID-19: development and prospective validation of a personalised risk prediction tool.

Kaitlin Swinnerton†, Nathanael R. Fillmore†, Austin Vo, Jennifer La, Danne Elbers, Mary Brophy, Nhan V. Do, Paul A. Monach‡, Westyn Branch-Elliman‡† Equal first authorship · ‡ Equal senior authorship

eClinicalMedicine81, 103114
U.S. Veterans and VA Data Retrospective Cohort Study COVID-19 Severe COVID-19 Predictive Modeling
2023

Maintaining the Utility of Coronavirus Disease 2019 Pandemic Severity Surveillance: Evaluation of Trends in Attributable Deaths and Development and Validation of a Measurement Tool.

Caitlin Trottier†, Jennifer La†, Lucy L. Li†, Majd Alsoubani, Austin D. Vo, Nathanael R. Fillmore, Westyn Branch-Elliman, Shira Doron‡, Paul A. Monach‡† Equal first authorship · ‡ Equal senior authorship

Clinical Infectious Diseases77(9), 1247-1256
COVID-19 U.S. Veterans and VA Data Logistic Regression Model Validation Pandemic Surveillance
2023

Coronavirus disease 2019 (COVID-19) hospitalization metrics that do not account for disease severity underestimate protection provided by severe acute respiratory coronavirus virus 2 (SARS-CoV-2) vaccination and boosting: A retrospective cohort study.

June K. Corrigan†, Jennifer La†, Nathanael R. Fillmore, Nhan V. Do, Mary Brophy, Shira Doron, Paul A. Monach‡, Westyn Branch-Elliman‡† Equal first authorship · ‡ Equal senior authorship

Infection Control and Hospital Epidemiology44(1), 149-151
U.S. Veterans and VA Data Retrospective Cohort Study Electronic Health Records COVID-19 Vaccine Effectiveness
2022

The COVID-19 hospitalization metric in the pre- and postvaccination eras as a measure of pandemic severity: A retrospective, nationwide cohort study.

Nathanael R. Fillmore†, Jennifer La†, Chunlei Zheng, Shira Doron, Nhan V. Do, Paul A. Monach‡, Westyn Branch-Elliman‡† Equal first authorship · ‡ Equal senior authorship

Infection Control and Hospital Epidemiology43(12), 1767-1772
U.S. Veterans and VA Data Retrospective Cohort Study COVID-19 Vaccine Effectiveness Hospitalization Metrics
2022

Association of COVID-19 Vaccination With SARS-CoV-2 Infection in Patients With Cancer: A US Nationwide Veterans Affairs Study.

Julie Tsu-Yu Wu†, Jennifer La†, Westyn Branch-Elliman, Linden B. Huhmann, Summer S. Han, Giovanni Parmigiani, David P. Tuck, Mary T. Brophy, Nhan V. Do, Albert Y. Lin‡, Nikhil C. Munshi‡, Nathanael R. Fillmore‡† Equal first authorship · ‡ Equal senior authorship

JAMA Oncology8(2), 281-286
U.S. Veterans and VA Data Retrospective Cohort Study COVID-19 Vaccine Effectiveness Cancer Patients
2020

An application to support COVID-19 occupational health and patient tracking at a Veterans Affairs medical center.

Nathanael R. Fillmore†, Danne C. Elbers†, Jennifer La, Theodore C. Feldman, Feng-Chi Sung, Robert B. Hall, Vinh Nguyen, Nicholas Link, Robert Zwolinski, Svitlana Dipietro, Steven J. Miller, Anahit Aleksanyan, Sergey D. Goryachev, Paul Corcoran, Steven J. Bergstrom, Michael A. Parenteau, Robert S. Sprague, David J. Thornton, Jane A. Driver, Judith M. Strymish, Stewart Evans, Benjamin Colonna, Mary T. Brophy, Nhan V. Do† Equal first authorship

Journal of the American Medical Informatics Association27(11), 1716-1720
COVID-19 Occupational Health Patient Tracking Contact Tracing Health Informatics