Topic

Age Factors

Fillmore has investigated the influence of advanced age on disease severity, treatment response, and clinical outcomes across various pathologies. His research demonstrates that while age is a primary predictor of severe COVID-19 in vaccinated adults, older patients may exhibit biomarkers, such as increased tumor mutational burden, that support a robust response to immune checkpoint therapy. Additionally, his work explores how age modulates the efficacy of prostate cancer therapies and affects the utilization of sentinel lymph node biopsies in melanoma patients.

U.S. Veterans and VA Data 4 Logistic Regression 3 Real World Evidence 3 Retrospective Cohort Study 3 Comparative Analysis 2 Patient Outcomes 2 Prostate Cancer 2 Cutaneous Melanoma 1 VA Cancer Registry 1 SEER Database 1 Sentinel Lymph Node Biopsy 1 Disease Staging 1

Publications (5)

2026

Sentinel lymph node biopsy utilization and positivity in veterans with cutaneous melanoma: A comparative analysis of the VA Cancer Registry and the SEER Program.

Daniel Y. Kim, Susan M. Swetter, Linden Huhmann, Jacqueline M. Ferguson, Kimberly Breglio, Allyson C. Spence, Lee Wheless, Mary T. Brophy, Nhan V. Do, Nathanael Fillmore^‡, Rebecca I. Hartman^‡^‡ Equal senior authorship

Journal of the American Academy of Dermatology

U.S. Veterans and VA Data Cutaneous Melanoma VA Cancer Registry SEER Database Sentinel Lymph Node Biopsy

2026

Active Surveillance Use for Favorable-Risk Prostate Cancer in a Veterans Affairs Population.

Grace Lee^†, John R. Bihn^†, John M. Culnan, Jennifer La, Nhan V. Do, Kenute Myrie, Channing J. Paller, Nathanael R. Fillmore^‡, Matthew R. Cooperberg^‡, PROFOUND-VET Investigators^† Equal first authorship · ^‡ Equal senior authorship

JAMA

Active Surveillance Age Factors Area Deprivation Index Clinical Oncology Clinical Practice Diffusion

2026

Abiraterone or Enzalutamide for Patients With Metastatic Castration-Sensitive Prostate Cancer: A Nationwide Veterans Affairs Study.

Jennifer La^†, Lin Wang^†, June K. Corrigan, Deborah Lang, Nhan V. Do, Mary T. Brophy, Nathanael R. Fillmore^‡, Channing J. Paller^‡^† Equal first authorship · ^‡ Equal senior authorship

JCO Clinical Cancer Informatics10(3), e2500213

U.S. Veterans and VA Data Retrospective Cohort Study Prostate Cancer Overall Survival Real World Evidence

2022

Factors Associated With Severe COVID-19 Among Vaccinated Adults Treated in US Veterans Affairs Hospitals.

Austin D. Vo^†, Jennifer La^†, Julie T-Y Wu, Judith M. Strymish, Matthew Ronan, Mary Brophy, Nhan V. Do, Westyn Branch-Elliman^‡, Nathanael R. Fillmore^‡, Paul A. Monach^‡^† Equal first authorship · ^‡ Equal senior authorship

JAMA Network Open5(10), e2240037

U.S. Veterans and VA Data Retrospective Cohort Study COVID-19 Severe COVID-19 Risk Factors

2021

Evaluating the impact of age on immune checkpoint therapy biomarkers.

Rossin Erbe, Zheyu Wang, Sharon Wu, Joanne Xiu, Neeha Zaidi, Jennifer La, David Tuck, Nathanael Fillmore, Nicolas A. Giraldo, Michael Topper, Stephen Baylin, Marc Lippman, Claudine Isaacs, Reva Basho, Ilya Serebriiskii, Heinz-Josef Lenz, Igor Astsaturov, John Marshall, Josephine Taverna, Jerry Lee, Elizabeth M. Jaffee, Torres Evanthia T. Roussos, Ashani Weeraratna, Hariharan Easwaran, Elana J. Fertig

Cell Reports36(8), 109599

Age Factors Biomarkers Comparative Analysis Genomic Analysis Immune Checkpoint Inhibitors