Topic

Cross Protection

Fillmore and his colleagues investigated the role of cross-protection conferred by seasonal human coronaviruses against SARS-CoV-2. Utilizing a Veterans Affairs cohort, he demonstrated that recent infections with HCoV-229E and HCoV-OC43 are associated with a significantly lower risk of subsequent SARS-CoV-2 infection. These findings suggest that prior exposure to common coronavirus strains may provide a degree of immunological protection against the virus that causes COVID-19.

U.S. Veterans and VA Data 1 Retrospective Cohort Study 1 Electronic Health Records 1 COVID-19 1 Cox Proportional Hazards Model 1 Human Coronaviruses 1 Epidemiology 1 Observational Study 1

Publications (1)

2022

Recent common human coronavirus infection protects against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: A Veterans Affairs cohort study.

Nathanael R. Fillmore, Raphael E. Szalat, Jennifer La, Westyn Branch-Elliman, Paul A. Monach, Vinh Nguyen, Mehmet K. Samur, Mary T. Brophy, Nhan V. Do, Nikhil C. Munshi

PNAS119(46), e2213783119

U.S. Veterans and VA Data Retrospective Cohort Study Electronic Health Records COVID-19 Cox Proportional Hazards Model