Genomic Analysis

Fillmore has focused on the integration of large-scale genomic data with clinical records to refine precision oncology and improve the accuracy of disease associations. His work demonstrates how molecular clustering can stratify advanced prostate cancer patients into targetable subgroups and how age-related genomic profiles influence responses to immune checkpoint therapy. Additionally, he has established the importance of rigorous phenotypic validation, showing that imprecise case definitions in electronic health records can lead to significant false positives in genome-wide association studies.