Nathanael R. Fillmore
Topics / Inverse Probability Weighting
Topic

Inverse Probability Weighting

Fillmore utilizes inverse probability weighting to mitigate confounding and selection bias in retrospective cohort studies. This methodology has enabled him to rigorously evaluate the comparative effectiveness of prostate cancer therapies and the long-term neuroprotective effects of metabolic medications in high-risk populations. By employing these weights, his work provides more robust estimates of treatment effects in real-world clinical settings.

U.S. Veterans and VA Data 5 Retrospective Cohort Study 5 Alzheimer Disease and Dementia 4 Cox Proportional Hazards Model 4 Prostate Cancer 3 Overall Survival 3 Comparative Effectiveness 3 Real World Evidence 2 Survival Analysis 2 Patient Outcomes 2 Metastatic Castration-Resistant Prostate Cancer 2 Framingham Heart Study 2

Publications (7)

2026

Sodium-Glucose Cotransporter 2 Inhibitors and Dementia Risk in Patients With Psychiatric Disorders.

David T. Liebers†, Tianshe He†, Rebecca A. Betensky, Chunlei Zheng, Kaitlin N. Swinnerton, Sean Jacobson, Linden Huhmann, Mary T. Brophy, Nhan V. Do, Paola Gilsanz, Ricardo S. Osorio, Nunzio Pomara, Antonio Convit, Donald C. Goff, Dan V. Iosifescu, Nathanael R. Fillmore, Jaime Ramos-Cejudo† Equal first authorship

JAMA Network Open9(6), e2619985
U.S. Veterans and VA Data Retrospective Cohort Study Electronic Health Records Alzheimer Disease and Dementia SGLT2 Inhibitors
2026

Docetaxel Rechallenge vs Cabazitaxel in Patients With Metastatic Castration-Resistant Prostate Cancer.

Pedro C. Barata†, June K. Corrigan†, Jennifer La, John M. Culnan, Elliot Akama-Garren, Karlynn N. Dulberger, Clark Dumontier, Jason Hansen, John R. Bihn, Rhonda L. Bitting, Mary T. Brophy, Heather H. Cheng, Matthew R. Cooperberg, Nhan V. Do, Tanya Dorff, Antonio Tito Fojo, J. Michael Gaziano, Sergey D. Goryachev, Susan Halabi, Richard L. Hauger, David M. Nanus, Timothy R. Rebbeck, Chong-Xian Pan, Martin W. Schoen, Kaitlin N. Swinnerton, Kenute Myrie, Rachel B. Ramoni, Nathanael R. Fillmore, Channing J. Paller‡, Matthew B. Rettig‡† Equal first authorship · ‡ Equal senior authorship

JAMA Network Open9(1), e2551231
U.S. Veterans and VA Data Retrospective Cohort Study Metastatic Castration-Resistant Prostate Cancer Prostate Cancer Comparative Effectiveness
2024

Antidepressant exposure and long-term dementia risk in a nationwide retrospective study on US veterans with midlife major depressive disorder.

Jaime Ramos-Cejudo†, June K. Corrigan†, Chunlei Zheng, Kaitlin N. Swinnerton, Sean R. Jacobson, Jennifer La, Rebecca A. Betensky, Ricardo S. Osorio, Sharon Madanes, Nunzio Pomara, Dan Iosifescu, Mary Brophy, Nhan V. Do‡, Nathanael R. Fillmore‡† Equal first authorship · ‡ Equal senior authorship

Alzheimer's & Dementia20(6), 4106-4114
U.S. Veterans and VA Data Retrospective Cohort Study Alzheimer Disease and Dementia Major Depressive Disorder Antidepressant Therapy
2022

Platelet Function Is Associated With Dementia Risk in the Framingham Heart Study.

Jaime Ramos-Cejudo, Andrew D. Johnson, Alexa Beiser, Sudha Seshadri, Joel Salinas, Jeffrey S. Berger, Nathanael R. Fillmore, Nhan Do, Chunlei Zheng, Zanetta Kovbasyuk, Babak A. Ardekani, Nunzio Pomara, Omonigho M. Bubu, Ankit Parekh, Antonio Convit, Rebecca A. Betensky, Thomas M. Wisniewski, Ricardo S. Osorio

Journal of the American Heart Association11(9), e023918
Alzheimer Disease and Dementia Framingham Heart Study Light Transmission Aggregometry Platelet Function Inverse Probability Weighting
2021

The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study.

Jaime Ramos-Cejudo, Andrew D. Johnson, Alexa Beiser, Sudha Seshadri, Joel Salinas, Jeffrey S. Berger, Nathanael R. Fillmore, Nhan Do, Chunlei Zheng, Zanetta Kovbasyuk, Babak A. Ardekani, Omonigho M. Bubu, Ankit Parekh, Antonio Convit, Rebecca A. Betensky, Thomas M. Wisniewski, Ricardo S. Osorio

Frontiers in Aging Neuroscience13, 773984
Alzheimer Disease and Dementia Framingham Heart Study Neutrophil-to-Lymphocyte Ratio Cox Proportional Hazards Model Inverse Probability Weighting