Monoclonal Gammopathy of Undetermined Significance

Fillmore and his collaborators have investigated the impact of plasma cell disorders, including monoclonal gammopathy of undetermined significance, on vaccine efficacy. His research demonstrates that patients with these conditions experience higher rates of SARS-CoV-2 breakthrough infections compared to matched controls. These findings suggest that the presence of a monoclonal gammopathy may impair the immune response to mRNA vaccines, even following the administration of booster doses.