Nathanael R. Fillmore
Topics / Overall Survival
Topic

Overall Survival

Fillmore has extensively investigated the determinants of overall survival across various malignancies, with a particular emphasis on the roles of frailty, multimorbidity, and healthcare access. His research demonstrates that electronic frailty indices and specific patterns of chronic illness are potent independent predictors of mortality in patients with multiple myeloma, acute myeloid leukemia, and non-small cell lung cancer. Additionally, he has identified critical survival disparities based on race and socioeconomic status, finding that equal access to healthcare within a single-payer system can reverse typical racial inequities in cancer survival.

U.S. Veterans and VA Data 28 Retrospective Cohort Study 24 Patient Outcomes 18 Survival Analysis 16 Cox Proportional Hazards Model 13 Real World Evidence 13 Frailty 10 Multiple Myeloma 10 Electronic Frailty Index 9 Cancer Patients 8 Electronic Health Records 7 Hospitalization Metrics 6

Publications (28)

2026

Association of Frailty With Transfusions, Hospitalizations, and Survival in Patients With Myelodysplastic Syndrome Initiating Hypomethylating Agents.

Anahid Hamparsumian†, Jennifer La†, Mayuri Dharne, Gary Gilbert, Mary T. Brophy, Nhan V. Do, Dae Hyun Kim, Jane A. Driver, Nathanael R. Fillmore‡, Clark DuMontier‡† Equal first authorship · ‡ Equal senior authorship

EJHaem7(4), e70352
U.S. Veterans and VA Data Retrospective Cohort Study Frailty Overall Survival Hospitalization Metrics
2026

Frailty and survival outcomes in veterans with invasive cutaneous melanoma: A Veterans Affairs Cancer Registry retrospective cohort study.

Linden B. Huhmann†, Jonathan C. Hwang†, Daniel Y. Kim, Kaelyn Nannini, Nhan V. Do, John M. Gaziano, Lee E. Wheless, Nathanael R. Fillmore‡, Rebecca I. Hartman‡† Equal first authorship · ‡ Equal senior authorship

Journal of the American Academy of Dermatology95(1), 240-243
U.S. Veterans and VA Data Retrospective Cohort Study Cancer-Associated Thrombosis Cutaneous Melanoma Overall Survival
2026

Docetaxel Rechallenge vs Cabazitaxel in Patients With Metastatic Castration-Resistant Prostate Cancer.

Pedro C. Barata†, June K. Corrigan†, Jennifer La, John M. Culnan, Elliot Akama-Garren, Karlynn N. Dulberger, Clark Dumontier, Jason Hansen, John R. Bihn, Rhonda L. Bitting, Mary T. Brophy, Heather H. Cheng, Matthew R. Cooperberg, Nhan V. Do, Tanya Dorff, Antonio Tito Fojo, J. Michael Gaziano, Sergey D. Goryachev, Susan Halabi, Richard L. Hauger, David M. Nanus, Timothy R. Rebbeck, Chong-Xian Pan, Martin W. Schoen, Kaitlin N. Swinnerton, Kenute Myrie, Rachel B. Ramoni, Nathanael R. Fillmore, Channing J. Paller‡, Matthew B. Rettig‡† Equal first authorship · ‡ Equal senior authorship

JAMA Network Open9(1), e2551231
U.S. Veterans and VA Data Retrospective Cohort Study Metastatic Castration-Resistant Prostate Cancer Prostate Cancer Comparative Effectiveness
2025

Potentially Inappropriate Medications, Frailty, and Outcomes in Patients With Cancer Managed in a National Health Care System.

Jennifer La, Tammy Hshieh, Anahid Hamparsumian, Robert Zwolinski, Jameson Wood, Mayuri Dharne, J. Michael Gaziano, Mary T. Brophy, Nhan V. Do, Nikhil C. Munshi, Jane A. Driver, Gregory A. Abel, Nathanael R. Fillmore‡, Clark DuMontier‡‡ Equal senior authorship

Journal of the National Comprehensive Cancer Network23(9), 363-370
U.S. Veterans and VA Data Retrospective Cohort Study Electronic Health Records Frailty Overall Survival
2025

Multimorbidity and Its Impact in Older U.S. Veterans Newly Treated for Advanced Non-Small Cell Lung Cancer.

Joseph R. Larsen†, Chunlei Zheng†, Jennifer La, Julie Tsu-Yu Wu, Michael Kelley, J. Michael Gaziano, Mary Brophy, Nhan V. Do, Dae H. Kim, Jane A. Driver, Clark DuMontier‡, Nathanael R. Fillmore‡† Equal first authorship · ‡ Equal senior authorship

Annals of the American Thoracic Society22(4), 598-608
U.S. Veterans and VA Data Retrospective Cohort Study Lung Cancer Overall Survival Geriatric Oncology
2024

Real-world effectiveness of immune checkpoint inhibitors and BRAF/MEK inhibitors among veteran patients with cutaneous melanoma.

Daniel Y. Kim, Susan M. Swetter, Linden Huhmann, Matthew P. Dizon, Jacqueline M. Ferguson, Thomas F. Osborne, Allyson C. Spence, Amina Ziad, Nathanael Fillmore‡, Rebecca I. Hartman‡‡ Equal senior authorship

Journal of the American Academy of Dermatology90(3), 620-623
U.S. Veterans and VA Data Retrospective Cohort Study Cutaneous Melanoma Immune Checkpoint Inhibitors BRAF/MEK Inhibitors
2024

Brain tumors in United States military veterans.

John R. Bihn†, Gino Cioffi†, Kristin A. Waite, Carol Kruchko, Corey Neff, Mackenzie Price, Quinn T. Ostrom, Kaitlin N. Swinnerton, Danne C. Elbers, Michael A. Mooney, Jacob Rachlin, Thor D. Stein, Mary T. Brophy, Nhan V. Do, Ryan E. Ferguson, David S. Priemer, Daniel P. Perl, Richard A. Hickman, Burt Nabors, Jennifer Rusiecki, Jill S. Barnholtz-Sloan‡, Nathanael R. Fillmore‡† Equal first authorship · ‡ Equal senior authorship

Neuro-oncology26(2), 387-396
U.S. Veterans and VA Data Primary Brain Tumors Overall Survival VA Cancer Registry Epidemiology
2023

More intensive therapy as more effective treatment for frail patients with multiple myeloma [corrected].

Clark DuMontier†, Jennifer La†, John Bihn, June Corrigan, Cenk Yildirim, Mayuri Dharne, Hamza Hassan, Sarvari Yellapragada, Gregory A. Abel, J. Michael Gaziano, Nhan V. Do, Mary Brophy, Dae H. Kim, Nikhil C. Munshi, Nathanael R. Fillmore‡, Jane A. Driver‡† Equal first authorship · ‡ Equal senior authorship

Blood Advances7(20), 6275-6284
U.S. Veterans and VA Data Retrospective Cohort Study Multiple Myeloma Frailty Overall Survival
2021

Defining Multimorbidity and Its Impact in Older United States Veterans Newly Treated for Multiple Myeloma.

Nathanael R. Fillmore†, Clark DuMontier†, Cenk Yildirim, Jennifer La, Mara M. Epstein, David Cheng, Diana Cirstea, Sarvari Yellapragada, Gregory A. Abel, J. Michael Gaziano, Nhan Do, Mary Brophy, Dae H. Kim, Nikhil C. Munshi, Jane A. Driver† Equal first authorship

Journal of the National Cancer Institute113(8), 1084-1093
U.S. Veterans and VA Data Retrospective Cohort Study Multiple Myeloma Overall Survival Geriatric Oncology
2021

Contemporary Analysis of Electronic Frailty Measurement in Older Adults with Multiple Myeloma Treated in the National US Veterans Affairs Healthcare System.

Clark DuMontier†, Nathanael R. Fillmore†, Cenk Yildirim, David Cheng, Jennifer La, Ariela R. Orkaby, Brian Charest, Diana Cirstea, Sarvari Yellapragada, John Michael Gaziano, Nhan Do, Mary T. Brophy, Dae H. Kim, Nikhil C. Munshi, Jane A. Driver† Equal first authorship

Cancers13(12)
U.S. Veterans and VA Data Retrospective Cohort Study Electronic Health Records Multiple Myeloma Frailty
2021

Updating and Validating the U.S. Veterans Affairs Frailty Index: Transitioning From ICD-9 to ICD-10.

David Cheng†, Clark DuMontier†, Cenk Yildirim, Brian Charest, Chelsea E. Hawley, Min Zhuo, Julie M. Paik, Enzo Yaksic, J. Michael Gaziano, Nhan Do, Mary Brophy, Kelly Cho, Dae H. Kim, Jane A. Driver, Nathanael R. Fillmore‡, Ariela R. Orkaby‡† Equal first authorship · ‡ Equal senior authorship

Journals of Gerontology: Series A76(7), 1318-1325
U.S. Veterans and VA Data Electronic Health Records Frailty Electronic Frailty Index ICD-10 Coding
2019

Machine Learning Methods to Predict Lung Cancer Survival Using the Veterans Affairs Research Precision Oncology Data Commons.

Nhan V. Do, Jaime C. Ramos, Nathanael R. Fillmore, Robert L. Grossman, Michael Fitzsimons, Danne C. Elbers, Frank Meng, Brett R. Johnson, Samuel Ajjarapu, Corri L. DeDomenico, Karen E. Pierce-Murray, Robert B. Hall, Andrew F. Do, Kelly Gaynor, Peter L. Elkin, Mary T. Brophy

Studies in Health Technology and Informatics264, 1453
U.S. Veterans and VA Data Lung Cancer Machine Learning Predictive Modeling Overall Survival