Nathanael R. Fillmore
Topics / Prostate Cancer
Topic

Prostate Cancer

Fillmore has conducted extensive research to optimize the management of prostate cancer through precision oncology, comparative effectiveness studies of systemic therapies, and the identification of cancer-related comorbidities. His work includes the development of machine learning tools and protein panels to predict cardiovascular risk and venous thromboembolism, as well as the use of natural language processing to standardize clinical data extraction. Additionally, he has evaluated the efficacy of docetaxel rechallenge and compared the outcomes of abiraterone and enzalutamide in both castration-sensitive and castration-resistant disease.

U.S. Veterans and VA Data 10 Retrospective Cohort Study 7 Real World Evidence 4 Patient Outcomes 4 Electronic Health Records 3 Observational Study 3 Overall Survival 3 Survival Analysis 3 Inverse Probability Weighting 3 Comparative Effectiveness 3 Risk Stratification 3 Cox Proportional Hazards Model 3

Publications (10)

2026

Development and External Validation of a Machine Learning-Based Risk Classification Score for Prostate Cancer-Specific Cardiovascular Risk.

Nickolas Stabellini, Tarek Nahle, Viraj Shah, Sai S. Kollapaneni, Omar M. Makram, Jennifer Cullen, Neal L. Weintraub, Harikrishnan H. Kunhiraman, Umang Swami, Morteza Mahmoudi, Nathanael Fillmore, Isla P. Garraway, Darryl Leong, Jehonathan Pinthus, John Shanahan, Alberto J. Montero, Neeraj Agarwal, Avirup Guha

JCO Oncology PracticeOP2600131
Prostate Cancer Cardiovascular Disease Cardio-Oncology Machine Learning Predictive Modeling
2026

Docetaxel Rechallenge vs Cabazitaxel in Patients With Metastatic Castration-Resistant Prostate Cancer.

Pedro C. Barata†, June K. Corrigan†, Jennifer La, John M. Culnan, Elliot Akama-Garren, Karlynn N. Dulberger, Clark Dumontier, Jason Hansen, John R. Bihn, Rhonda L. Bitting, Mary T. Brophy, Heather H. Cheng, Matthew R. Cooperberg, Nhan V. Do, Tanya Dorff, Antonio Tito Fojo, J. Michael Gaziano, Sergey D. Goryachev, Susan Halabi, Richard L. Hauger, David M. Nanus, Timothy R. Rebbeck, Chong-Xian Pan, Martin W. Schoen, Kaitlin N. Swinnerton, Kenute Myrie, Rachel B. Ramoni, Nathanael R. Fillmore, Channing J. Paller‡, Matthew B. Rettig‡† Equal first authorship · ‡ Equal senior authorship

JAMA Network Open9(1), e2551231
U.S. Veterans and VA Data Retrospective Cohort Study Metastatic Castration-Resistant Prostate Cancer Prostate Cancer Comparative Effectiveness
2026

Magnetic Resonance Imaging or Confirmatory Biopsy for Patients With Prostate Cancer Receiving Active Surveillance.

Matthew R. Cooperberg†, John R. Bihn†, John M. Culnan, Jennifer La, Sergey D. Goryachev, Daniel C. R. Chen, Oleg Soloviev, Grace Lee, June K. Corrigan, Kaitlin N. Swinnerton, Nicholas G. Nickols, Karlynn N. Dulberger, Pedro Barata, Rhonda L. Bitting, Mary T. Brophy, Heather H. Cheng, Hoedt Amanda De, Nhan V. Do, Stephen J. Freedland, Isla P. Garraway, J. Michael Gaziano, Susan Halabi, Richard L. Hauger, Stacy Loeb, David M. Nanus, Timothy R. Rebbeck, Matthew B. Rettig, Chong-Xian Pan, Kenute Myrie, Rachel B. Ramoni, Nathanael R. Fillmore‡, Channing J. Paller‡† Equal first authorship · ‡ Equal senior authorship

JAMA Oncology12(1), 111-113
U.S. Veterans and VA Data Retrospective Cohort Study Electronic Health Records Prostate Cancer Active Surveillance
2025

Automated Extraction of Imaging and Pathology Data From Diverse Prostate Cancer Electronic Records.

John M. Culnan, Sergey D. Goryachev, John R. Bihn, Grace Lee, Daniel C. R. Chen, Oleg Soloviev, Robert Zwolinski, Karlynn N. Dulberger, Nhan V. Do, Channing J. Paller, Matthew R. Cooperberg‡, Nathanael R. Fillmore‡‡ Equal senior authorship

JCO Clinical Cancer Informatics9, e2500085
U.S. Veterans and VA Data Electronic Health Records Prostate Cancer Natural Language Processing VA Cancer Registry
2023

Prostate cancer patient stratification by molecular signatures in the Veterans Precision Oncology Data Commons.

Kyle M. Hernandez†, Aarti Venkat†, Danne C. Elbers†, John R. Bihn, Mary T. Brophy, Nhan V. Do, Jennifer La, Qiong Liu, Andrew Prokhorenkov, Noah Metoki-Shlubsky, Feng-Chi Sung, Channing J. Paller‡, Nathanael R. Fillmore‡, Robert L. Grossman‡† Equal first authorship · ‡ Equal senior authorship

Cold Spring Harbor Molecular Case Studies9(4)
U.S. Veterans and VA Data Retrospective Cohort Study Prostate Cancer Metastatic Castration-Resistant Prostate Cancer Precision Oncology
2023

Allostatic load and cardiovascular outcomes in males with prostate cancer.

Nickolas Stabellini, Jennifer Cullen, Marcio S. Bittencourt, Justin X. Moore, Lifen Cao, Neal L. Weintraub, Ryan A. Harris, Xiaoling Wang, Biplab Datta, Steven S. Coughlin, Jorge Garcia, John Shanahan, Nelson Hamerschlak, Kristin Waite, Nathanael R. Fillmore, Martha Terris, Alberto J. Montero, Jill S. Barnholtz-Sloan‡, Avirup Guha‡‡ Equal senior authorship

JNCI Cancer Spectrum7(2)
Allostatic Load Cardiovascular Disease Major Adverse Cardiovascular Events Prostate Cancer Fine-Gray Models