Nathanael R. Fillmore
Topics / Risk Factors
Topic

Risk Factors

Fillmore has conducted extensive research to identify clinical and environmental risk factors for neurodegenerative diseases, malignancies, and acute complications. His work has established the role of systemic inflammation and platelet reactivity as predictors of dementia, as well as the impact of immunosuppression and comorbidities on severe COVID-19 outcomes. Additionally, he has investigated drivers of melanoma and thromboembolism, identifying key risk factors including Agent Orange exposure, Parkinson's disease, and specific antineoplastic therapies.

U.S. Veterans and VA Data 18 Retrospective Cohort Study 15 Logistic Regression 9 Cox Proportional Hazards Model 7 Hematologic Malignancies 7 Race and Ethnicity 6 Electronic Health Records 6 COVID-19 6 Cutaneous Melanoma 5 Survival Analysis 5 Observational Study 5 Alzheimer Disease and Dementia 5

Publications (22)

2026

A retrospective cohort study using the Veterans Affairs Cancer Registry database: Increased hazard of Parkinson's disease in United States Veterans with melanoma.

Linden B. Huhmann†, Jonathan C. Hwang†, David Perez, Daniel Y. Kim, Kaelyn Nannini, Nhan V. Do, John M. Gaziano, Mary T. Brophy, Lee E. Wheless, Nathanael R. Fillmore‡, Rebecca I. Hartman‡† Equal first authorship · ‡ Equal senior authorship

Journal of the American Academy of Dermatology
Cutaneous Melanoma Parkinson's Disease Retrospective Cohort Study U.S. Veterans and VA Data VA Cancer Registry
2026

Risk and protective factors for uveal melanoma: Evidence for a protective role of autoimmune and immune-mediated conditions.

Charles Lu†, Debby Cheng†, Andrew Mu, Olivia Burke, Lirit Fuksman, Priya Katyal, Sara Khattab, Nga Nguyen, Emma Beagles, Crystal Chang, Suzanne Xu, Jonathan C. Hwang, Linden Huhmann, Nicholas Starink, Martin A. Weinstock, Maryam M. Asgari, Marc S. Hurlbert, John M. Gaziano, Nathanael R. Fillmore, Rebecca I. Hartman, Yevgeniy R. Semenov† Equal first authorship

Journal of the American Academy of Dermatology95(1), 211-214
U.S. Veterans and VA Data Case-Control Study Uveal Melanoma Cutaneous Melanoma Logistic Regression
2026

Parkinson's disease and risk of melanoma in United States veterans: A Veterans Affairs Cancer Registry retrospective cohort study.

Jonathan C. Hwang†, Linden B. Huhmann†, David Perez, Daniel Y. Kim, Kaelyn Nannini, Nhan V. Do, John M. Gaziano, Mary T. Brophy, Lee E. Wheless, Nathanael R. Fillmore‡, Rebecca I. Hartman‡† Equal first authorship · ‡ Equal senior authorship

Journal of the American Academy of Dermatology94(6), 1811-1814
U.S. Veterans and VA Data Retrospective Cohort Study VA Cancer Registry Parkinson's Disease Cutaneous Melanoma
2026

Risk factors for the development of acral melanoma: A multi-institutional, retrospective cohort study.

Charles Lu†, Olivia Burke†, Christopher J. Thang, Sara Khattab, Nga Nguyen, Emma Beagles, Crystal Chang, Suzanne Xu, Jonathan C. Hwang, Linden Huhmann, Nicholas Starink, Martin A. Weinstock, Maryam M. Asgari, Marc S. Hurlbert, John M. Gaziano, Nathanael R. Fillmore, Theodore C. Feldman, Rebecca I. Hartman, Yevgeniy R. Semenov† Equal first authorship

JAAD international28, 38-46
Acral Melanoma Race and Ethnicity Risk Factors Retrospective Cohort Study Logistic Regression
2026

Neutrophil inflammation metrics are associated with the risk of future dementia in large data from NYU Langone Hospitals and the Veterans Health Administration.

Tianshe He, Rebecca A. Betensky, Ricardo S. Osorio, Kaitlin Swinnerton, Chunlei Zheng, Tovia Jacobs, Alok Vedvyas, Karyn Marsh, Joshua Chodosh, Ula Y. Hwang, Natalia Sifnugel, Omonigho M. Bubu, Thomas Wisniewski, Mary Brophy, Nhan V. Do, Nathanael R. Fillmore‡, Jaime Ramos-Cejudo‡‡ Equal senior authorship

Alzheimer's & Dementia22(4), e71335
U.S. Veterans and VA Data Retrospective Cohort Study Electronic Health Records Alzheimer Disease and Dementia Risk Factors
2026

Identification of Risk Factors for Acral Melanoma in US Veterans.

Jonathan C. Hwang†, Linden B. Huhmann†, Kelly Cho, Sergey D. Goryachev, Nicholas Starink, Martin A. Weinstock, Maryam M. Asgari, Christy Zheng, Charles Lu, Theodore C. Feldman, Nhan V. Do, John M. Gaziano, Yevgeniy R. Semenov, Marc S. Hurlbert, Nathanael R. Fillmore‡, Rebecca I. Hartman‡† Equal first authorship · ‡ Equal senior authorship

JAMA Dermatology162(3), 279-291
Acral Melanoma Agent Orange Exposure U.S. Veterans and VA Data VA Cancer Registry Nested Case-Control Study
2024

Thrombosis risk prediction in lymphoma patients: A multi-institutional, retrospective model development and validation study.

Shengling Ma†, Jennifer La†, Kaitlin N. Swinnerton, Danielle Guffey, Raka Bandyo, Las Pozas Giordana De, Katy Hanzelka, Xiangjun Xiao, Cristhiam M. Rojas-Hernandez, Christopher I. Amos, Vipul Chitalia, Katya Ravid, Kelly W. Merriman, Christopher R. Flowers, Nathanael Fillmore‡, Ang Li‡† Equal first authorship · ‡ Equal senior authorship

American Journal of Hematology99(7), 1230-1239
U.S. Veterans and VA Data Retrospective Cohort Study Cancer-Associated Thrombosis Lymphoma Predictive Modeling
2023

Epidemiology of Cancer-Associated Venous Thromboembolism in Patients With Solid and Hematologic Neoplasms in the Veterans Affairs Health Care System.

Kylee L. Martens†, Ang Li†, Jennifer La, Sarah B. May, Kaitlin N. Swinnerton, Hannah Tosi, Danne C. Elbers, Nhan V. Do, Mary T. Brophy, J. Michael Gaziano, Saran Lotfollahzadeh, Vipul Chitalia, Katya Ravid, Nathanael R. Fillmore† Equal first authorship

JAMA Network Open6(6), e2317945
U.S. Veterans and VA Data Retrospective Cohort Study Electronic Health Records Cancer-Associated Thrombosis Health Disparities
2023

Allostatic load and cardiovascular outcomes in males with prostate cancer.

Nickolas Stabellini, Jennifer Cullen, Marcio S. Bittencourt, Justin X. Moore, Lifen Cao, Neal L. Weintraub, Ryan A. Harris, Xiaoling Wang, Biplab Datta, Steven S. Coughlin, Jorge Garcia, John Shanahan, Nelson Hamerschlak, Kristin Waite, Nathanael R. Fillmore, Martha Terris, Alberto J. Montero, Jill S. Barnholtz-Sloan‡, Avirup Guha‡‡ Equal senior authorship

JNCI Cancer Spectrum7(2)
Allostatic Load Cardiovascular Disease Major Adverse Cardiovascular Events Prostate Cancer Fine-Gray Models
2022

Platelet Function Is Associated With Dementia Risk in the Framingham Heart Study.

Jaime Ramos-Cejudo, Andrew D. Johnson, Alexa Beiser, Sudha Seshadri, Joel Salinas, Jeffrey S. Berger, Nathanael R. Fillmore, Nhan Do, Chunlei Zheng, Zanetta Kovbasyuk, Babak A. Ardekani, Nunzio Pomara, Omonigho M. Bubu, Ankit Parekh, Antonio Convit, Rebecca A. Betensky, Thomas M. Wisniewski, Ricardo S. Osorio

Journal of the American Heart Association11(9), e023918
Alzheimer Disease and Dementia Framingham Heart Study Light Transmission Aggregometry Platelet Function Inverse Probability Weighting
2021

The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study.

Jaime Ramos-Cejudo, Andrew D. Johnson, Alexa Beiser, Sudha Seshadri, Joel Salinas, Jeffrey S. Berger, Nathanael R. Fillmore, Nhan Do, Chunlei Zheng, Zanetta Kovbasyuk, Babak A. Ardekani, Omonigho M. Bubu, Ankit Parekh, Antonio Convit, Rebecca A. Betensky, Thomas M. Wisniewski, Ricardo S. Osorio

Frontiers in Aging Neuroscience13, 773984
Alzheimer Disease and Dementia Framingham Heart Study Neutrophil-to-Lymphocyte Ratio Cox Proportional Hazards Model Inverse Probability Weighting