Target Trial Emulation

Fillmore employs target trial emulation to address the inherent biases of observational data and more accurately estimate the causal effects of pharmacological interventions. His work in this area has demonstrated that sodium-glucose cotransporter 2 inhibitors are associated with a reduced risk of all-cause dementia and fewer psychiatric emergency department visits among older adults with mood or psychotic disorders. This approach allows for a rigorous evaluation of neuroprotective benefits in high-risk populations where randomized controlled trials may be impractical.