Nathanael R. Fillmore
Topics / U.S. Veterans and VA Data
Topic

U.S. Veterans and VA Data

Fillmore has extensively utilized Department of Veterans Affairs data to investigate disparities in cancer outcomes and the prognostic impact of frailty and multimorbidity in older veterans. His research includes the development of the Veterans Precision Oncology Data Commons and various machine learning tools to improve risk stratification for venous thromboembolism and lung cancer. Additionally, he has conducted large-scale analyses of COVID-19 vaccination effectiveness and breakthrough infection risks among high-risk veteran populations.

Retrospective Cohort Study 57 Electronic Health Records 43 Real World Evidence 37 Patient Outcomes 31 Overall Survival 28 Survival Analysis 22 Cox Proportional Hazards Model 22 COVID-19 21 Risk Factors 18 Cancer Patients 18 VA Cancer Registry 17 Logistic Regression 16

Publications (97)

2026

Sentinel lymph node biopsy utilization and positivity in veterans with cutaneous melanoma: A comparative analysis of the VA Cancer Registry and the SEER Program.

Daniel Y. Kim, Susan M. Swetter, Linden Huhmann, Jacqueline M. Ferguson, Kimberly Breglio, Allyson C. Spence, Lee Wheless, Mary T. Brophy, Nhan V. Do, Nathanael Fillmore‡, Rebecca I. Hartman‡‡ Equal senior authorship

Journal of the American Academy of Dermatology
U.S. Veterans and VA Data Cutaneous Melanoma VA Cancer Registry SEER Database Sentinel Lymph Node Biopsy
2026

A retrospective cohort study using the Veterans Affairs Cancer Registry database: Increased hazard of Parkinson's disease in United States Veterans with melanoma.

Linden B. Huhmann†, Jonathan C. Hwang†, David Perez, Daniel Y. Kim, Kaelyn Nannini, Nhan V. Do, John M. Gaziano, Mary T. Brophy, Lee E. Wheless, Nathanael R. Fillmore‡, Rebecca I. Hartman‡† Equal first authorship · ‡ Equal senior authorship

Journal of the American Academy of Dermatology
Cutaneous Melanoma Parkinson's Disease Retrospective Cohort Study U.S. Veterans and VA Data VA Cancer Registry
2026

Association of Frailty With Transfusions, Hospitalizations, and Survival in Patients With Myelodysplastic Syndrome Initiating Hypomethylating Agents.

Anahid Hamparsumian†, Jennifer La†, Mayuri Dharne, Gary Gilbert, Mary T. Brophy, Nhan V. Do, Dae Hyun Kim, Jane A. Driver, Nathanael R. Fillmore‡, Clark DuMontier‡† Equal first authorship · ‡ Equal senior authorship

EJHaem7(4), e70352
U.S. Veterans and VA Data Retrospective Cohort Study Frailty Overall Survival Hospitalization Metrics
2026

Development and validation of venous thromboembolism-bidirectional encoder representations from transformers (VTE-BERT) natural language processing model.

Omid Jafari, Shengling Ma, Barbara D. Lam, Jun Y. Jiang, Emily Zhou, Mrinal Ranjan, Justine Ryu, Raka Bandyo, Arash Maghsoudi, Bo Peng, Christopher I. Amos, Abiodun Oluyomi, Nathanael R. Fillmore, Jennifer La‡, Ang Li‡‡ Equal senior authorship

Journal of Thrombosis and Haemostasis24(7), 2522-2531
Natural Language Processing External Validation Clinical Notes Radiology and Pathology Reports Cancer Patients
2026

Frailty and survival outcomes in veterans with invasive cutaneous melanoma: A Veterans Affairs Cancer Registry retrospective cohort study.

Linden B. Huhmann†, Jonathan C. Hwang†, Daniel Y. Kim, Kaelyn Nannini, Nhan V. Do, John M. Gaziano, Lee E. Wheless, Nathanael R. Fillmore‡, Rebecca I. Hartman‡† Equal first authorship · ‡ Equal senior authorship

Journal of the American Academy of Dermatology95(1), 240-243
U.S. Veterans and VA Data Retrospective Cohort Study Cancer-Associated Thrombosis Cutaneous Melanoma Overall Survival
2026

Risk and protective factors for uveal melanoma: Evidence for a protective role of autoimmune and immune-mediated conditions.

Charles Lu†, Debby Cheng†, Andrew Mu, Olivia Burke, Lirit Fuksman, Priya Katyal, Sara Khattab, Nga Nguyen, Emma Beagles, Crystal Chang, Suzanne Xu, Jonathan C. Hwang, Linden Huhmann, Nicholas Starink, Martin A. Weinstock, Maryam M. Asgari, Marc S. Hurlbert, John M. Gaziano, Nathanael R. Fillmore, Rebecca I. Hartman, Yevgeniy R. Semenov† Equal first authorship

Journal of the American Academy of Dermatology95(1), 211-214
U.S. Veterans and VA Data Case-Control Study Uveal Melanoma Cutaneous Melanoma Logistic Regression
2026

Parkinson's disease and risk of melanoma in United States veterans: A Veterans Affairs Cancer Registry retrospective cohort study.

Jonathan C. Hwang†, Linden B. Huhmann†, David Perez, Daniel Y. Kim, Kaelyn Nannini, Nhan V. Do, John M. Gaziano, Mary T. Brophy, Lee E. Wheless, Nathanael R. Fillmore‡, Rebecca I. Hartman‡† Equal first authorship · ‡ Equal senior authorship

Journal of the American Academy of Dermatology94(6), 1811-1814
U.S. Veterans and VA Data Retrospective Cohort Study VA Cancer Registry Parkinson's Disease Cutaneous Melanoma
2026

Sodium-Glucose Cotransporter 2 Inhibitors and Dementia Risk in Patients With Psychiatric Disorders.

David T. Liebers†, Tianshe He†, Rebecca A. Betensky, Chunlei Zheng, Kaitlin N. Swinnerton, Sean Jacobson, Linden Huhmann, Mary T. Brophy, Nhan V. Do, Paola Gilsanz, Ricardo S. Osorio, Nunzio Pomara, Antonio Convit, Donald C. Goff, Dan V. Iosifescu, Nathanael R. Fillmore, Jaime Ramos-Cejudo† Equal first authorship

JAMA Network Open9(6), e2619985
U.S. Veterans and VA Data Retrospective Cohort Study Electronic Health Records Alzheimer Disease and Dementia SGLT2 Inhibitors
2026

Development and External Validation of a Machine Learning-Based Risk Classification Score for Prostate Cancer-Specific Cardiovascular Risk.

Nickolas Stabellini, Tarek Nahle, Viraj Shah, Sai S. Kollapaneni, Omar M. Makram, Jennifer Cullen, Neal L. Weintraub, Harikrishnan H. Kunhiraman, Umang Swami, Morteza Mahmoudi, Nathanael Fillmore, Isla P. Garraway, Darryl Leong, Jehonathan Pinthus, John Shanahan, Alberto J. Montero, Neeraj Agarwal, Avirup Guha

JCO Oncology PracticeOP2600131
Prostate Cancer Cardiovascular Disease Cardio-Oncology Machine Learning Predictive Modeling
2026

A deep learning model to dynamically predict cancer-associated thromboembolism in large-scale healthcare systems.

Tianshe He†, Chunlei Zheng†, Jennifer La, Dang Pham, Omid Jafari, Jamie Strampe, Karlynn Dulberger, Jaime Ramos-Cejudo, J. Michael Gaziano, Nhan V. Do, Vipul Chitalia, Katya Ravid, Ang Li‡, Nathanael R. Fillmore‡† Equal first authorship · ‡ Equal senior authorship

npj Digital Medicine
U.S. Veterans and VA Data Electronic Health Records Cancer-Associated Thrombosis Predictive Modeling External Validation
2026

Neutrophil inflammation metrics are associated with the risk of future dementia in large data from NYU Langone Hospitals and the Veterans Health Administration.

Tianshe He, Rebecca A. Betensky, Ricardo S. Osorio, Kaitlin Swinnerton, Chunlei Zheng, Tovia Jacobs, Alok Vedvyas, Karyn Marsh, Joshua Chodosh, Ula Y. Hwang, Natalia Sifnugel, Omonigho M. Bubu, Thomas Wisniewski, Mary Brophy, Nhan V. Do, Nathanael R. Fillmore‡, Jaime Ramos-Cejudo‡‡ Equal senior authorship

Alzheimer's & Dementia22(4), e71335
U.S. Veterans and VA Data Retrospective Cohort Study Electronic Health Records Alzheimer Disease and Dementia Risk Factors
2026

Identification of Risk Factors for Acral Melanoma in US Veterans.

Jonathan C. Hwang†, Linden B. Huhmann†, Kelly Cho, Sergey D. Goryachev, Nicholas Starink, Martin A. Weinstock, Maryam M. Asgari, Christy Zheng, Charles Lu, Theodore C. Feldman, Nhan V. Do, John M. Gaziano, Yevgeniy R. Semenov, Marc S. Hurlbert, Nathanael R. Fillmore‡, Rebecca I. Hartman‡† Equal first authorship · ‡ Equal senior authorship

JAMA Dermatology162(3), 279-291
Acral Melanoma Agent Orange Exposure U.S. Veterans and VA Data VA Cancer Registry Nested Case-Control Study
2026

Docetaxel Rechallenge vs Cabazitaxel in Patients With Metastatic Castration-Resistant Prostate Cancer.

Pedro C. Barata†, June K. Corrigan†, Jennifer La, John M. Culnan, Elliot Akama-Garren, Karlynn N. Dulberger, Clark Dumontier, Jason Hansen, John R. Bihn, Rhonda L. Bitting, Mary T. Brophy, Heather H. Cheng, Matthew R. Cooperberg, Nhan V. Do, Tanya Dorff, Antonio Tito Fojo, J. Michael Gaziano, Sergey D. Goryachev, Susan Halabi, Richard L. Hauger, David M. Nanus, Timothy R. Rebbeck, Chong-Xian Pan, Martin W. Schoen, Kaitlin N. Swinnerton, Kenute Myrie, Rachel B. Ramoni, Nathanael R. Fillmore, Channing J. Paller‡, Matthew B. Rettig‡† Equal first authorship · ‡ Equal senior authorship

JAMA Network Open9(1), e2551231
U.S. Veterans and VA Data Retrospective Cohort Study Metastatic Castration-Resistant Prostate Cancer Prostate Cancer Comparative Effectiveness
2026

Magnetic Resonance Imaging or Confirmatory Biopsy for Patients With Prostate Cancer Receiving Active Surveillance.

Matthew R. Cooperberg†, John R. Bihn†, John M. Culnan, Jennifer La, Sergey D. Goryachev, Daniel C. R. Chen, Oleg Soloviev, Grace Lee, June K. Corrigan, Kaitlin N. Swinnerton, Nicholas G. Nickols, Karlynn N. Dulberger, Pedro Barata, Rhonda L. Bitting, Mary T. Brophy, Heather H. Cheng, Hoedt Amanda De, Nhan V. Do, Stephen J. Freedland, Isla P. Garraway, J. Michael Gaziano, Susan Halabi, Richard L. Hauger, Stacy Loeb, David M. Nanus, Timothy R. Rebbeck, Matthew B. Rettig, Chong-Xian Pan, Kenute Myrie, Rachel B. Ramoni, Nathanael R. Fillmore‡, Channing J. Paller‡† Equal first authorship · ‡ Equal senior authorship

JAMA Oncology12(1), 111-113
U.S. Veterans and VA Data Retrospective Cohort Study Electronic Health Records Prostate Cancer Active Surveillance
2026

Rule-based natural language processing to extract clinical trial and research study enrollment history from unstructured notes.

Sergey D. Goryachev†, Julie Tsu-Yu Wu†, Eric Lin†, Daphne R. Friedman, Robert Zwolinski, Rupali Dhond, Danne C. Elbers, Jennifer La, Cenk Yildirim, June K. Corrigan, Daniel C. R. Chen, Mary T. Brophy, Nhan V. Do‡, Nathanael R. Fillmore‡† Equal first authorship · ‡ Equal senior authorship

Health Informatics Journal32(1), 14604582261430614
U.S. Veterans and VA Data Electronic Health Records Natural Language Processing Rule-Based Algorithms Clinical Notes
2025

Rapid Support and Implementation of an Application for the Prediction Augmented Screening Initiative (PASI) Planning Phase Through the Enabling Technologies for Rapid Learning Health Systems Platform (ENTHRALL) at the Department of Veterans Affairs (VA).

Hannah M. Tosi, Chunlei Zheng, Amelia H. Tarren, Meghana Yellanki, Stephen J. Miller, Oleg V. Soloviev, June K. Corrigan, George R. Schneeloch, Hormuzd A. Katki, Lauren E. Kearney, Tanner J. Caverly, Nichole T. Tanner, Renda Soylemez Wiener, Mary Brophy, Nathanael R. Fillmore, Nhan V. Do, Danne C. Elbers

Cancer Informatics24, 11769351251389781
U.S. Veterans and VA Data Electronic Health Records Lung Cancer Natural Language Processing Learning Health Systems
2025

Potentially Inappropriate Medications, Frailty, and Outcomes in Patients With Cancer Managed in a National Health Care System.

Jennifer La, Tammy Hshieh, Anahid Hamparsumian, Robert Zwolinski, Jameson Wood, Mayuri Dharne, J. Michael Gaziano, Mary T. Brophy, Nhan V. Do, Nikhil C. Munshi, Jane A. Driver, Gregory A. Abel, Nathanael R. Fillmore‡, Clark DuMontier‡‡ Equal senior authorship

Journal of the National Comprehensive Cancer Network23(9), 363-370
U.S. Veterans and VA Data Retrospective Cohort Study Electronic Health Records Frailty Overall Survival
2025

Automated Extraction of Imaging and Pathology Data From Diverse Prostate Cancer Electronic Records.

John M. Culnan, Sergey D. Goryachev, John R. Bihn, Grace Lee, Daniel C. R. Chen, Oleg Soloviev, Robert Zwolinski, Karlynn N. Dulberger, Nhan V. Do, Channing J. Paller, Matthew R. Cooperberg‡, Nathanael R. Fillmore‡‡ Equal senior authorship

JCO Clinical Cancer Informatics9, e2500085
U.S. Veterans and VA Data Electronic Health Records Prostate Cancer Natural Language Processing VA Cancer Registry
2025

Multimorbidity and Its Impact in Older U.S. Veterans Newly Treated for Advanced Non-Small Cell Lung Cancer.

Joseph R. Larsen†, Chunlei Zheng†, Jennifer La, Julie Tsu-Yu Wu, Michael Kelley, J. Michael Gaziano, Mary Brophy, Nhan V. Do, Dae H. Kim, Jane A. Driver, Clark DuMontier‡, Nathanael R. Fillmore‡† Equal first authorship · ‡ Equal senior authorship

Annals of the American Thoracic Society22(4), 598-608
U.S. Veterans and VA Data Retrospective Cohort Study Lung Cancer Overall Survival Geriatric Oncology
2025

Leveraging near-real-time patient and population data to incorporate fluctuating risk of severe COVID-19: development and prospective validation of a personalised risk prediction tool.

Kaitlin Swinnerton†, Nathanael R. Fillmore†, Austin Vo, Jennifer La, Danne Elbers, Mary Brophy, Nhan V. Do, Paul A. Monach‡, Westyn Branch-Elliman‡† Equal first authorship · ‡ Equal senior authorship

eClinicalMedicine81, 103114
U.S. Veterans and VA Data Retrospective Cohort Study COVID-19 Severe COVID-19 Predictive Modeling
2025

The impact of imprecise case definitions in electronic health record research: a melanoma case-study from the Million Veteran Program.

Lee Wheless†, Dominique Mosley†, Daniel Dochtermann, Saiju Pyarajan, Katlyn Gonzalez, Rachel Weiss, Kyle Maas, Siwei Zhang, Lydia Yao, Yaomin Xu, Christopher Madden, Jacqueline Ike, Isabelle T. Smith, Sarah Grossarth, Otis Wilson, Adriana Hung, Nathanael R. Fillmore, Kevin Brown, Maria Teresa Landi, Rebecca I. Hartman, VA Million Veteran Program† Equal first authorship

Archives of Dermatological Research317(1), 308
Electronic Health Records Genome-Wide Association Study Million Veteran Program Cutaneous Melanoma Case Definition Validation
2024

Natural Language Processing Algorithm to Extract Multiple Myeloma Stage From Oncology Notes in the Veterans Affairs Healthcare System.

Sergey D. Goryachev†, Cenk Yildirim†, Clark DuMontier†, Jennifer La†, Mayuri Dharne, J. Michael Gaziano, Mary T. Brophy, Nikhil C. Munshi, Jane A. Driver, Nhan V. Do‡, Nathanael R. Fillmore‡† Equal first authorship · ‡ Equal senior authorship

JCO Clinical Cancer Informatics8, e2300197
U.S. Veterans and VA Data Electronic Health Records Multiple Myeloma Natural Language Processing VA Cancer Registry
2024

Thrombosis risk prediction in lymphoma patients: A multi-institutional, retrospective model development and validation study.

Shengling Ma†, Jennifer La†, Kaitlin N. Swinnerton, Danielle Guffey, Raka Bandyo, Las Pozas Giordana De, Katy Hanzelka, Xiangjun Xiao, Cristhiam M. Rojas-Hernandez, Christopher I. Amos, Vipul Chitalia, Katya Ravid, Kelly W. Merriman, Christopher R. Flowers, Nathanael Fillmore‡, Ang Li‡† Equal first authorship · ‡ Equal senior authorship

American Journal of Hematology99(7), 1230-1239
U.S. Veterans and VA Data Retrospective Cohort Study Cancer-Associated Thrombosis Lymphoma Predictive Modeling
2024

Antidepressant exposure and long-term dementia risk in a nationwide retrospective study on US veterans with midlife major depressive disorder.

Jaime Ramos-Cejudo†, June K. Corrigan†, Chunlei Zheng, Kaitlin N. Swinnerton, Sean R. Jacobson, Jennifer La, Rebecca A. Betensky, Ricardo S. Osorio, Sharon Madanes, Nunzio Pomara, Dan Iosifescu, Mary Brophy, Nhan V. Do‡, Nathanael R. Fillmore‡† Equal first authorship · ‡ Equal senior authorship

Alzheimer's & Dementia20(6), 4106-4114
U.S. Veterans and VA Data Retrospective Cohort Study Alzheimer Disease and Dementia Major Depressive Disorder Antidepressant Therapy
2024

Real-world effectiveness of immune checkpoint inhibitors and BRAF/MEK inhibitors among veteran patients with cutaneous melanoma.

Daniel Y. Kim, Susan M. Swetter, Linden Huhmann, Matthew P. Dizon, Jacqueline M. Ferguson, Thomas F. Osborne, Allyson C. Spence, Amina Ziad, Nathanael Fillmore‡, Rebecca I. Hartman‡‡ Equal senior authorship

Journal of the American Academy of Dermatology90(3), 620-623
U.S. Veterans and VA Data Retrospective Cohort Study Cutaneous Melanoma Immune Checkpoint Inhibitors BRAF/MEK Inhibitors
2024

Brain tumors in United States military veterans.

John R. Bihn†, Gino Cioffi†, Kristin A. Waite, Carol Kruchko, Corey Neff, Mackenzie Price, Quinn T. Ostrom, Kaitlin N. Swinnerton, Danne C. Elbers, Michael A. Mooney, Jacob Rachlin, Thor D. Stein, Mary T. Brophy, Nhan V. Do, Ryan E. Ferguson, David S. Priemer, Daniel P. Perl, Richard A. Hickman, Burt Nabors, Jennifer Rusiecki, Jill S. Barnholtz-Sloan‡, Nathanael R. Fillmore‡† Equal first authorship · ‡ Equal senior authorship

Neuro-oncology26(2), 387-396
U.S. Veterans and VA Data Primary Brain Tumors Overall Survival VA Cancer Registry Epidemiology
2024

Matching Patients to Accelerate Clinical Trials (MPACT): Enabling Technology for Oncology Clinical Trial Workflow.

Nhan V. Do, Danne C. Elbers, Nathanael R. Fillmore, Samuel Ajjarapu, Steven J. Bergstrom, John Bihn, June K. Corrigan, Rupali Dhond, Svitlana Dipietro, Arkadiy Dolgin, Theodore C. Feldman, Sergey D. Goryachev, Linden B. Huhmann, Jennifer La, Paul A. Marcantonio, Kyle M. McGrath, Stephen J. Miller, Vinh Q. Nguyen, George R. Schneeloch, Feng-Chi Sung, Kaitlin N. Swinnerton, Amelia H. Tarren, Hannah M. Tosi, Danielle Valley, Austin D. Vo, Cenk Yildirim, Chunlei Zheng, Robert Zwolinski, Gisele A. Sarosy, David Loose, Colleen Shannon, Mary T. Brophy

Studies in Health Technology and Informatics310, 1086-1090
U.S. Veterans and VA Data Electronic Health Records Natural Language Processing Clinical Trial Enrollment Patient Screening Workflow
2023

Prostate cancer patient stratification by molecular signatures in the Veterans Precision Oncology Data Commons.

Kyle M. Hernandez†, Aarti Venkat†, Danne C. Elbers†, John R. Bihn, Mary T. Brophy, Nhan V. Do, Jennifer La, Qiong Liu, Andrew Prokhorenkov, Noah Metoki-Shlubsky, Feng-Chi Sung, Channing J. Paller‡, Nathanael R. Fillmore‡, Robert L. Grossman‡† Equal first authorship · ‡ Equal senior authorship

Cold Spring Harbor Molecular Case Studies9(4)
U.S. Veterans and VA Data Retrospective Cohort Study Prostate Cancer Metastatic Castration-Resistant Prostate Cancer Precision Oncology
2023

Construct validity of the electronic Veterans Affairs Frailty Index against clinician frailty assessment.

Clark DuMontier†, Robert Hennis†, Cenk Yilidirim, Benjamin J. Seligman, Valencia Carolina Fonseca, Brooke L. Lubinski, Stephanie M. Sison, Mayuri Dharne, Dae Hyun Kim, Andrea Wershof Schwartz, Jane A. Driver, Nathanael R. Fillmore‡, Ariela R. Orkaby‡† Equal first authorship · ‡ Equal senior authorship

Journal of the American Geriatrics Society71(12), 3857-3864
U.S. Veterans and VA Data Electronic Health Records Frailty Electronic Frailty Index Construct Validity
2023

Maintaining the Utility of Coronavirus Disease 2019 Pandemic Severity Surveillance: Evaluation of Trends in Attributable Deaths and Development and Validation of a Measurement Tool.

Caitlin Trottier†, Jennifer La†, Lucy L. Li†, Majd Alsoubani, Austin D. Vo, Nathanael R. Fillmore, Westyn Branch-Elliman, Shira Doron‡, Paul A. Monach‡† Equal first authorship · ‡ Equal senior authorship

Clinical Infectious Diseases77(9), 1247-1256
COVID-19 U.S. Veterans and VA Data Logistic Regression Model Validation Pandemic Surveillance
2023

More intensive therapy as more effective treatment for frail patients with multiple myeloma [corrected].

Clark DuMontier†, Jennifer La†, John Bihn, June Corrigan, Cenk Yildirim, Mayuri Dharne, Hamza Hassan, Sarvari Yellapragada, Gregory A. Abel, J. Michael Gaziano, Nhan V. Do, Mary Brophy, Dae H. Kim, Nikhil C. Munshi, Nathanael R. Fillmore‡, Jane A. Driver‡† Equal first authorship · ‡ Equal senior authorship

Blood Advances7(20), 6275-6284
U.S. Veterans and VA Data Retrospective Cohort Study Multiple Myeloma Frailty Overall Survival
2023

Machine learning-based natural language processing to extract PD-L1 expression levels from clinical notes.

Eric Lin†, Robert Zwolinski†, Julie Tsu-Yu Wu, Jennifer La, Sergey Goryachev, Linden Huhmann, Cenk Yildrim, David P. Tuck, Danne C. Elbers, Mary T. Brophy, Nhan V. Do‡, Nathanael R. Fillmore‡† Equal first authorship · ‡ Equal senior authorship

Health Informatics Journal29(3), 14604582231198021
U.S. Veterans and VA Data Electronic Health Records Natural Language Processing Machine Learning PD-L1 Expression
2023

Derivation and Validation of a Clinical Risk Assessment Model for Cancer-Associated Thrombosis in Two Unique US Health Care Systems.

Ang Li†, Jennifer La†, Sarah B. May, Danielle Guffey, Costa Wilson L. da, Christopher I. Amos, Raka Bandyo, Emily M. Milner, Karen M. Kurian, Daniel C. R. Chen, Nhan V. Do, Carolina Granada, Nimrah Riaz, Mary T. Brophy, Vipul Chitalia, J. Michael Gaziano, David A. Garcia, Marc Carrier, Christopher R. Flowers, Neil A. Zakai‡, Nathanael R. Fillmore‡† Equal first authorship · ‡ Equal senior authorship

Journal of Clinical Oncology41(16), 2926-2938
Cancer-Associated Thrombosis Predictive Modeling Retrospective Cohort Study External Validation U.S. Veterans and VA Data
2023

Epidemiology of Cancer-Associated Venous Thromboembolism in Patients With Solid and Hematologic Neoplasms in the Veterans Affairs Health Care System.

Kylee L. Martens†, Ang Li†, Jennifer La, Sarah B. May, Kaitlin N. Swinnerton, Hannah Tosi, Danne C. Elbers, Nhan V. Do, Mary T. Brophy, J. Michael Gaziano, Saran Lotfollahzadeh, Vipul Chitalia, Katya Ravid, Nathanael R. Fillmore† Equal first authorship

JAMA Network Open6(6), e2317945
U.S. Veterans and VA Data Retrospective Cohort Study Electronic Health Records Cancer-Associated Thrombosis Health Disparities
2023

A deep learning algorithm to predict risk of pancreatic cancer from disease trajectories.

Davide Placido†, Bo Yuan†, Jessica X. Hjaltelin†, Chunlei Zheng†, Amalie D. Haue, Piotr J. Chmura, Chen Yuan, Jihye Kim, Renato Umeton, Gregory Antell, Alexander Chowdhury, Alexandra Franz, Lauren Brais, Elizabeth Andrews, Debora S. Marks, Aviv Regev, Siamack Ayandeh, Mary T. Brophy, Nhan V. Do, Peter Kraft, Brian M. Wolpin, Michael H. Rosenthal, Nathanael R. Fillmore, Søren Brunak‡, Chris Sander‡† Equal first authorship · ‡ Equal senior authorship

Nature Medicine29(5), 1113-1122
U.S. Veterans and VA Data Electronic Health Records Pancreatic Cancer Predictive Modeling Deep Learning
2023

Validation of algorithms to select patients with multiple myeloma and patients initiating myeloma treatment in the national Veterans Affairs Healthcare System.

Jennifer La†, Clark DuMontier†, Hamza Hassan, Maya Abdallah, Camille Edwards, Karina Verma, Grace Ferri, Mayuri Dharne, Cenk Yildirim, June Corrigan, J. Michael Gaziano, Nhan V. Do, Mary T. Brophy, Jane A. Driver, Nikhil C. Munshi, Nathanael R. Fillmore† Equal first authorship

Pharmacoepidemiology and Drug Safety32(5), 558-566
U.S. Veterans and VA Data Electronic Health Records Multiple Myeloma VA Cancer Registry Algorithm Validation
2023

Allostatic load and cardiovascular outcomes in males with prostate cancer.

Nickolas Stabellini, Jennifer Cullen, Marcio S. Bittencourt, Justin X. Moore, Lifen Cao, Neal L. Weintraub, Ryan A. Harris, Xiaoling Wang, Biplab Datta, Steven S. Coughlin, Jorge Garcia, John Shanahan, Nelson Hamerschlak, Kristin Waite, Nathanael R. Fillmore, Martha Terris, Alberto J. Montero, Jill S. Barnholtz-Sloan‡, Avirup Guha‡‡ Equal senior authorship

JNCI Cancer Spectrum7(2)
Allostatic Load Cardiovascular Disease Major Adverse Cardiovascular Events Prostate Cancer Fine-Gray Models
2023

Coronavirus disease 2019 (COVID-19) hospitalization metrics that do not account for disease severity underestimate protection provided by severe acute respiratory coronavirus virus 2 (SARS-CoV-2) vaccination and boosting: A retrospective cohort study.

June K. Corrigan†, Jennifer La†, Nathanael R. Fillmore, Nhan V. Do, Mary Brophy, Shira Doron, Paul A. Monach‡, Westyn Branch-Elliman‡† Equal first authorship · ‡ Equal senior authorship

Infection Control and Hospital Epidemiology44(1), 149-151
U.S. Veterans and VA Data Retrospective Cohort Study Electronic Health Records COVID-19 Vaccine Effectiveness
2022

The COVID-19 hospitalization metric in the pre- and postvaccination eras as a measure of pandemic severity: A retrospective, nationwide cohort study.

Nathanael R. Fillmore†, Jennifer La†, Chunlei Zheng, Shira Doron, Nhan V. Do, Paul A. Monach‡, Westyn Branch-Elliman‡† Equal first authorship · ‡ Equal senior authorship

Infection Control and Hospital Epidemiology43(12), 1767-1772
U.S. Veterans and VA Data Retrospective Cohort Study COVID-19 Vaccine Effectiveness Hospitalization Metrics
2022

Increased relative proportions of advanced melanoma among veterans: A comparative analysis with the Surveillance, Epidemiology, and End Results registry.

Michael S. Chang†, Jennifer La†, Nicole Trepanowski, David Cheng, John R. Bihn, Nhan Do, Mary Brophy, Nathanael R. Fillmore‡, Rebecca I. Hartman‡† Equal first authorship · ‡ Equal senior authorship

Journal of the American Academy of Dermatology87(1), 72-79
VA Cancer Registry SEER Database U.S. Veterans and VA Data Cutaneous Melanoma Melanoma Specific Survival
2022

Potential long-term effect of tumor necrosis factor inhibitors on dementia risk: A propensity score matched retrospective cohort study in US veterans.

Chunlei Zheng†, Nathanael R. Fillmore†, Jaime Ramos-Cejudo, Mary Brophy, Ricardo Osorio, Mark E. Gurney, Wei Qiao Qiu, Rhoda Au, George Perry, Maureen Dubreuil, Shu G. Chen, Xin Qi, Pamela B. Davis, Nhan Do, Rong Xu† Equal first authorship

Alzheimer's & Dementia18(6), 1248-1259
U.S. Veterans and VA Data Retrospective Cohort Study TNF Inhibitors Alzheimer Disease and Dementia Propensity Score Matching
2022

Association of COVID-19 Vaccination With SARS-CoV-2 Infection in Patients With Cancer: A US Nationwide Veterans Affairs Study.

Julie Tsu-Yu Wu†, Jennifer La†, Westyn Branch-Elliman, Linden B. Huhmann, Summer S. Han, Giovanni Parmigiani, David P. Tuck, Mary T. Brophy, Nhan V. Do, Albert Y. Lin‡, Nikhil C. Munshi‡, Nathanael R. Fillmore‡† Equal first authorship · ‡ Equal senior authorship

JAMA Oncology8(2), 281-286
U.S. Veterans and VA Data Retrospective Cohort Study COVID-19 Vaccine Effectiveness Cancer Patients
2021

Defining Multimorbidity and Its Impact in Older United States Veterans Newly Treated for Multiple Myeloma.

Nathanael R. Fillmore†, Clark DuMontier†, Cenk Yildirim, Jennifer La, Mara M. Epstein, David Cheng, Diana Cirstea, Sarvari Yellapragada, Gregory A. Abel, J. Michael Gaziano, Nhan Do, Mary Brophy, Dae H. Kim, Nikhil C. Munshi, Jane A. Driver† Equal first authorship

Journal of the National Cancer Institute113(8), 1084-1093
U.S. Veterans and VA Data Retrospective Cohort Study Multiple Myeloma Overall Survival Geriatric Oncology
2021

Contemporary Analysis of Electronic Frailty Measurement in Older Adults with Multiple Myeloma Treated in the National US Veterans Affairs Healthcare System.

Clark DuMontier†, Nathanael R. Fillmore†, Cenk Yildirim, David Cheng, Jennifer La, Ariela R. Orkaby, Brian Charest, Diana Cirstea, Sarvari Yellapragada, John Michael Gaziano, Nhan Do, Mary T. Brophy, Dae H. Kim, Nikhil C. Munshi, Jane A. Driver† Equal first authorship

Cancers13(12)
U.S. Veterans and VA Data Retrospective Cohort Study Electronic Health Records Multiple Myeloma Frailty
2021

Updating and Validating the U.S. Veterans Affairs Frailty Index: Transitioning From ICD-9 to ICD-10.

David Cheng†, Clark DuMontier†, Cenk Yildirim, Brian Charest, Chelsea E. Hawley, Min Zhuo, Julie M. Paik, Enzo Yaksic, J. Michael Gaziano, Nhan Do, Mary Brophy, Kelly Cho, Dae H. Kim, Jane A. Driver, Nathanael R. Fillmore‡, Ariela R. Orkaby‡† Equal first authorship · ‡ Equal senior authorship

Journals of Gerontology: Series A76(7), 1318-1325
U.S. Veterans and VA Data Electronic Health Records Frailty Electronic Frailty Index ICD-10 Coding
2020

An application to support COVID-19 occupational health and patient tracking at a Veterans Affairs medical center.

Nathanael R. Fillmore†, Danne C. Elbers†, Jennifer La, Theodore C. Feldman, Feng-Chi Sung, Robert B. Hall, Vinh Nguyen, Nicholas Link, Robert Zwolinski, Svitlana Dipietro, Steven J. Miller, Anahit Aleksanyan, Sergey D. Goryachev, Paul Corcoran, Steven J. Bergstrom, Michael A. Parenteau, Robert S. Sprague, David J. Thornton, Jane A. Driver, Judith M. Strymish, Stewart Evans, Benjamin Colonna, Mary T. Brophy, Nhan V. Do† Equal first authorship

Journal of the American Medical Informatics Association27(11), 1716-1720
COVID-19 Occupational Health Patient Tracking Contact Tracing Health Informatics
2019

Machine Learning Methods to Predict Lung Cancer Survival Using the Veterans Affairs Research Precision Oncology Data Commons.

Nhan V. Do, Jaime C. Ramos, Nathanael R. Fillmore, Robert L. Grossman, Michael Fitzsimons, Danne C. Elbers, Frank Meng, Brett R. Johnson, Samuel Ajjarapu, Corri L. DeDomenico, Karen E. Pierce-Murray, Robert B. Hall, Andrew F. Do, Kelly Gaynor, Peter L. Elkin, Mary T. Brophy

Studies in Health Technology and Informatics264, 1453
U.S. Veterans and VA Data Lung Cancer Machine Learning Predictive Modeling Overall Survival
2019

The Veterans Precision Oncology Data Commons: Transforming VA data into a national resource for research in precision oncology.

Nhan Do, Robert Grossman, Theodore Feldman, Nathanael Fillmore, Danne Elbers, David Tuck, Rupali Dhond, Luis Selva, Frank Meng, Michael Fitzsimons, Samuel Ajjarapu, Siamack Ayandeh, Robert Hall, Stephanie Do, Mary Brophy

Seminars in Oncology46(4-5), 314-320
U.S. Veterans and VA Data Electronic Health Records Precision Oncology Data Sharing Platform Clinical Informatics