Vaccine Adverse Events

Fillmore and his colleagues have investigated the influence of prior SARS-CoV-2 infection on the safety profiles of mRNA vaccinations. Their research demonstrates that previously infected patients, particularly older adults with significant comorbidities, exhibit a transient increase in hospitalization rates following a second vaccine dose. These findings suggest that prior infection may alter the clinical response to vaccination, highlighting the importance of optimizing dosing schedules to minimize adverse events.