Nathanael R. Fillmore
Topics / Vaccine Effectiveness
Topic

Vaccine Effectiveness

Fillmore has examined vaccine effectiveness across diverse and high-risk populations, with a particular focus on patients with cancer, plasma cell disorders, and those receiving immunosuppressive therapy. His research demonstrates that while mRNA vaccination significantly reduces the risk of infection and severe illness, certain comorbidities and treatments can impair the immune response and increase the likelihood of breakthrough infections. Furthermore, he has established that utilizing clinical severity metrics, such as oxygen requirements, provides a more accurate measure of vaccine protection than simple hospitalization counts.

U.S. Veterans and VA Data 7 COVID-19 7 Retrospective Cohort Study 6 Severe COVID-19 5 Electronic Health Records 4 Observational Study 4 mRNA Vaccines 3 Matched Cohort Study 3 Hospitalization Metrics 3 Real World Evidence 3 Immunosuppressive Therapy 2 Multiple Myeloma 2

Publications (7)

2023

Coronavirus disease 2019 (COVID-19) hospitalization metrics that do not account for disease severity underestimate protection provided by severe acute respiratory coronavirus virus 2 (SARS-CoV-2) vaccination and boosting: A retrospective cohort study.

June K. Corrigan†, Jennifer La†, Nathanael R. Fillmore, Nhan V. Do, Mary Brophy, Shira Doron, Paul A. Monach‡, Westyn Branch-Elliman‡† Equal first authorship · ‡ Equal senior authorship

Infection Control and Hospital Epidemiology44(1), 149-151
U.S. Veterans and VA Data Retrospective Cohort Study Electronic Health Records COVID-19 Vaccine Effectiveness
2022

The COVID-19 hospitalization metric in the pre- and postvaccination eras as a measure of pandemic severity: A retrospective, nationwide cohort study.

Nathanael R. Fillmore†, Jennifer La†, Chunlei Zheng, Shira Doron, Nhan V. Do, Paul A. Monach‡, Westyn Branch-Elliman‡† Equal first authorship · ‡ Equal senior authorship

Infection Control and Hospital Epidemiology43(12), 1767-1772
U.S. Veterans and VA Data Retrospective Cohort Study COVID-19 Vaccine Effectiveness Hospitalization Metrics
2022

Association of COVID-19 Vaccination With SARS-CoV-2 Infection in Patients With Cancer: A US Nationwide Veterans Affairs Study.

Julie Tsu-Yu Wu†, Jennifer La†, Westyn Branch-Elliman, Linden B. Huhmann, Summer S. Han, Giovanni Parmigiani, David P. Tuck, Mary T. Brophy, Nhan V. Do, Albert Y. Lin‡, Nikhil C. Munshi‡, Nathanael R. Fillmore‡† Equal first authorship · ‡ Equal senior authorship

JAMA Oncology8(2), 281-286
U.S. Veterans and VA Data Retrospective Cohort Study COVID-19 Vaccine Effectiveness Cancer Patients